Clinical pharmacologist Harry Shirkey noted more than 50 years ago that children are often “therapeutic orphans” in biomedical research. Today, we see a continued five- to 10-year lag of pediatric biomedical advances behind the adult populations.

In pediatric healthcare, approximately 90% of healthcare resources are utilized by 5 to 10% of children who suffer complex and chronic medical conditions. In many cases, these 5,000 pediatric-only rare conditions, or “orphan diseases,” lack a market large enough to drive intervention, which permeates both the pharmaceutical and biomedical device industries.

Engineering Medicine
Mung Chiang
Krach Institute for Tech...